Latest news 2017:
Published in Proceedings of the National Academy of Sciences of the United States of America (PNAS) (IF = 9.7): Human papillomavirus oncoproteins induce a reorganization of epithelial-associated gamma delta T cells promoting tumor formation. Van Hede D, Polese B, Humblet C, Wilharm A, Renoux V, Dortu E, de Leval L, Delvenne P, Desmet CJ, Bureau F, Vermeijlen D (co-last author) & Jacobs N. (2017) doi: 10.1073/pnas.1712883114. [Epub ahead of print].
3 Welbio awardees in the LCMI lab: Pr. Fabrice Bureau (Continuation Grant 2017), Dr. Christophe Desmet (Starting Grant 2015), and Dr. Thomas Marichal (Starting Grant 2017).
Published in Nature Medicine (IF = 30.4): Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbations. Toussaint M, Jackson DJ, Swieboda D, Guedán A, Tsourouktsoglou TD, Ching YM, Radermecker C, Makrinioti H, Aniscenko J, Edwards MR, Solari R, Farnir F, Papayannopoulos V, Bureau F (co-last author), Marichal T (co-last author), Johnston SL.(2017) 23(6):681-691; doi: 10.1038/nm.4332.
Published in Immunity (IF = 24.1): Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages. Sabatel C, Radermecker C, Fievez L, Paulissen G, Chakarov S, Fernandes C, Olivier S, Toussaint M, Pirottin D, Xiao X, Quatresooz P, Sirard JC, Cataldo D, Gillet L, Bouabe H, Desmet CJ, Ginhoux F, Marichal T (co-last author), Bureau F. (2017) , 46(3):457-473.
Our laboratory is part of the GIGA (Interdisciplinary cluster for genoproteomics) research center of the University of Liege, in Belgium. The GIGA is composed of more than 500 researchers with various background and a common interest in medicine, physiology and molecular and cellular biology. Our integration to the GIGA allows us to benefit from state-of-the-art technological platforms, notably in the fields of imaging-flow cytometry, geno-transcriptomics, proteomics and bioinformatics. The GIGA is physically connected to the CHU, which greatly facilitates and stimulates translational studies.
Integrated since 2003 to the GIGA-Research Center, the LCMI has a long experience in cellular and molecular immunology. Our research is divided into four main themes (Lung myeloid cells, Molecular Immunology, Innate lymphocytes and Vaccinology) and focuses mainly on the cellular and molecular mechanisms at the interface between innate and adaptive immunity that underlie immune tolerance, allergy development or protective immunity. Using the most recent animal models, we thereby aim at contributing to a better understanding of the regulatory and effector pathways of immunity that contribute to health and disease.
The LCMI has been continuously growing and is now composed of 21 members with varied professional experience (biologists, veterinarians, bioengineers, pharmacists), creating a young, dynamic and international research environment. The Unit is also benefiting from administrative associates and animal care technicians that are shared by other laboratories within the GIGA-Research Center.
We work in tight cooperation with other collaborators in Belgium and across the world (among others, Pr. Stephen J. Galli from Stanford University, Pr. Ken J Ishii from Osaka University, Pr. Sebatian Johnston from Imperial College London), as well as with industrial partners.
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