The mechanisms of cellular adaptation are crucial in various physiological and pathophysiological contexts. During cancer development, tumor cells develop strategies to escape physiological regulation and to adapt to changing environments. These involve modifications in protein signaling, gene expression and protein synthesis. By the combination of classical biochemistry, molecular screenings and the use of in vivo models of cancer, our lab investigates the molecular mechanisms that promote cancer cell adaptation during tumor development and resistance to therapies. By studying novel proteins/ enzymes involved in cancer cell adaptation, we seek to shed light on new mechanisms promoting tumor adaptation essential for cancer biology and to identify novel therapeutic strategies in the treatment of invasive or resistant human cancers.
Legend: Cellular signaling of cancer cells is subjected to various modifications for instance after oncogenic transformation, upon increased ligand concentration, or under therapeutic pressure. These ultimately converge to promote cancer cell adaptation, tumor development and resistance to therapies