Thomas Marichal has just been awarded a prestigious ERC Starting Grant (1.5 M€ - 5 years) to fund a project called 'IM-ID', which will investigate in depth the identity and function of a lung regulatory macrophage population that proves to be a promising novel target to treat asthma.
At the end of last week, the FNRS granted new funding for major equipment, Télévie research projects and new mandates. The zebrafish platform receives funding to improve its equipment and the cyclotron platform will improve the measurement capabilities of the 7TMRI. 14 researchers are awarded a new mandate and 10 get renewal. And finally, some twenty projects are financed by Télévie.
Thanks to new genomic techniques, the Animal Genomics Unit, led by Michel Georges, in collaboration with the Laboratory of Gastroenterology led by Edouard Louis (GIGA-Medical Genomics) has been able to refine its work to identify the genes responsible for Crohn’s disease. This study, published today in Nature Communications, suggests new potential targets for the development of new treatments.
Researchers from ULB and ULiège (GIGA-Cancer) are making progress in understanding the interaction between immune cells and cancer cells, via the deregulation of the epigenetic machinery. Their study is published in the journal Science Advances.
A team of researchers led by Pierre Close has uncovered a novel therapeutic opportunity in the treatment of melanoma that acquired resistance to targeted therapies. In collaboration with researchers from VIB, they have revealed that malignant melanomas reprogram their protein synthesis machinery and become addicted to a new family of enzymes that modify transfer RNAs during acquired resistance. Strikingly, the inhibition of these molecules synergies with targeted therapies to produce a strong anti-tumoral effect.
Alain Chariot's team (Laboratory of Medical Chemistry) shows that the CEMIP protein plays a role in resistance to targeted therapies for colorectal cancers. By associating one targeted therapy with a pharmacological treatment that inhibits this protein, we could treat relapses in patients with this type of tumor.
Marc Muller (Laboratory for Organogenesis and Regeneration) won the second prize of the Airbus challenge from INNOspace (Space Administration of the German Aerospace Center - DLR) with the "FISHinSPACE" project, which suggets zebrafish larvae to study vertebrate physiology in space
Olivier Peulen's group at the Metastasis Research Laboratory (LRM, Vincenzo Castronovo and Akeila Bellahcene, GIGA-Cancer) shows that inhibition of myoferline may limit resistance to chemotherapy by modifying the metabolism of pancreatic malignant cells in patients with this cancer.
In collaboration with a team from the University of Vienna, researchers from the Laboratory of Hematology (GIGA-ULiège and CHU) demonstrate the potential of the OTSSP167 inhibitor of the MELK kinase both to limit the proliferation of cancer cells and to prevent and resorb bone complications, that most patients with myeloma developed.
A GIGA-Neuroscience team (Laurent Nguyen's lab) has identified an additional function of the p27 protein in the control of axonal transport, which is required for the maturation and survival of neurons, as well as for the transmission of nerve impulses. This discovery could shed some new light on the pathophysiological mechanisms of some neurodegenerative diseases such as Parkinson's or Huntington's diseases, which are characterized by impaired axonal transport. Their results have just been released in the prestigious scientific journal Cell Reports.
The conclusions of the annual meeting of the European Society of Endocrinology (ECE 2018) in Barcelona mentioned the results of a study conducted by Julie Bakker (GIGA-Neurosciences) and colleagues from the center of expertise on Gender Dysphoria of the UL University Medical Center (Netherlands), which shows thatbrain activity and structure in transgender adolescents more closely resembles the typical activation patterns of their desired gender than of the one of birth.
The GIGA-Cell Imaging platform can now offer state of the art multiphoton imaging microscopy with the Nikon AR1 MP+ multiphoton microscope.
In collaboration with a team at the University of California at Los Angeles (UCLA), researchers from GIGA-Neurosciences have discovered a new gene responsible for a seizure syndrome called juvenile myoclonic epilepsy (JME). This discovery was made as part of an international consortium that studies genetic abnormalities responsible for epileptic diseases. It is being published this week in the New England Journal of Medicine, one of the most prestigious international medical journals.
For the last few months, lightsheet microscopy has been available in the GIGA Cell Imaging Platform. And in a few weeks, the platform will also have an Incucyte S3 analysis system. All-new advanced technologies, managed by platform experts, that give new imaging possibilities for researchers.
À Liège, la Semaine Internationale du Cerveau se concentrera sur le thème "Soigner le cerveau et ses maladies : des neurosciences aux soins intégrés". Elle se concrétise par l’organisation de plusieurs activités la semaine prochaine. N'hésitez pas à venir rencontrer nos chercheurs lors du Café des Sciences lundi soir !
Une équipe du GIGA vient de découvrir l’existence un dialogue moléculaire spécifique entre les interneurones inhibiteurs en migration et les cellules souches des neurones excitateurs qui se révèle nécessaire au développement du cortex cérébral. Les chercheurs ont découvert que ce crosstalk conditionne le développement harmonieux du cortex et que son altération pourrait expliquer le développement de la macrocéphalie voire de l’autisme. Leurs résultats sont publiés dans la prestigieuse revue scientifique Cell.
The team of Cécile Oury (Laboratory of Thrombosis Haemostasis - GIGA-Cardiovascular) shows that nucleotides activate platelets and therefore the risk of cardiovascular accident but that it is possible to cancel this effect with a drug available on the market.
“News & Views” - the new item written by PhD students after each GIGA conference. This article is linked to the conference of Pr. Antoine Adamantidis of the University of Bern.
The Cyclotron Research Center (GIGA-CRC In Vivo Imaging) has created a new Facebook page. The opportunity also to talk about the new website www.cognap.uliege.be about the study of siesta and to remind you that the center regularly looks for volunteers (40 years and more) for the study of cognitive aging. If you want to help research, do not hesitate!
Akeila Bellahcène, who co-directs the Metastases Research Laboratory with Vincent Castronovo, has been elected president of the Belgian Association for the Study of Cancer (ABEC). This appointment is also an opportunity to honor all the researchers of the GIGA-Cancer unit and more broadly all those working on topics related to cancer. Congratulations to her!
A research team led by Julie Bakker (GIGA) and Ulrich Boehm (Saarland University) has made a major advancement in our understanding of how the brain controls sex. The discovery that kisspeptin controls both attraction and sexual desire opens up exciting new possibilities for the development of treatments for low sexual desire.
VitriCell SA, providing innovative and efficient solutions for cryopreservation of even the most sensitive cells, disclosed yesterday that it closed a series A round of fundraising in the second half of 2017 totaling over €1 million ($1.2M). Funds raised will enable launch this year of first products based on aseptic vitrification, a new cell cryopreservation method. VitriCell is a GIGA resulting spin-off and moved to business premises in the GIGA tower last October.
“News & Views” - the. new item written by PhD students after each GIGA conference. This article is linked to the conference of Pr. Bart de Strooper from the Center for Brain and Disease Research at the University of Leuven.
GIGA researchers are involved in 6 projects selected by the EOS program, a collaborative program between the north and south of the country (FNRS and FWO), with 120 million over 4 years. A total of 38 research projects will be funded for Belgium. This is a nice encouragement for the research conducted at GIGA!
A team of researchers from ZIKAlliance, of which Laurent Nguyen's lab is part, discovers a specific mechanism of the infection.
Liesbet Geris, responsable du laboratoire de génie biomécanique au sein de l’unité In silico Medecine (GIGA) vient d’être sélectionnée pour recevoir un ERC Consolidator Grant pour son projet INSITE. Dotée de 2.161.750€ cette bourse lui a été attribuée pour continuer ses recherches qui s’intéressent au développement de nouvelles stratégies in silico (à l’aide de modèles numériques) dans le domaine du génie tissulaire.
Sylvain Delaunay, chercheur au GIGA Insitute, est le lauréat du Prix Scientifique McKinsey & Company 2017. Pourvu d’un montant de 5.000 €, ce prix récompense les chercheurs qui ont pu prouver la pertinence sociale et économique de leur thèse ou leur applicabilité concrète.
“News & Views” is a new item written by PhD students as a part of the course “Reading and understanding scientific literature and presentations” offered by GIGA Graduate School. After each GIGA conference, students will write an article. The first one was linked to the conference of Dr Masayo Takahshi.
GIGA has submitted its 2017-2021 strategic plan to the ULiège authorities. GIGA’s 2017-2021 strategic plan is the foundation for the “labélisation” procedure that should recognize GIGA as first official interdisciplinary research institute of ULiège in 2018.
We are delighted to present the new GIGA logo, in line with the new visual identity of the University of Liège. Declined directly from the logo of the University, it nevertheless takes the specific colors of the GIGA.
Le lundi 18 décembre, l'unité du Centre de Recherches du Cyclotron - CRC - met a l'honneur un cycle de conférences portant sur différents aspects du vieillissement : Vieillissons ! L'objectif est de présenter les résultats de différentes études menées au sein du Centre, de communiquer avec le public et de partager nos expériences.
Le GIGA-Consciousness et le Coma Science Group ont le plaisir de vous inviter à la 3ème journée européenne du coma qui aura lieu ce mercredi 8 novembre 2017 de 18h00 à 21h00 à la Salle Académique de l'Université de Liège, place du XX Août sur la thématique du don d'organes.
From 1 January, Liesbet Geris will begin a three-year term as Francqui Research Professor. An enviable mandate that, according to the terms of the Francqui Foundation, "is aimed at researchers whose research is novel and exceptional and whose field of research belongs to an important and current scientific area".
In a study published today in the journal Nature Immunology, Belgian researchers from the universities of Liège and Ghent (ULiège and UGent) have, for the first time, proven that infecting laboratory mice with a gammaherpesvirus, herpesvirus murin 4 or MuHV-4, protects the latter from developing allergic asthma. This study is the first to prove the crucial role that some viral infections can play in the long-term control of the development of allergic responses.
A joint study by ULiège (GIGA) and ULB, will be publish in PNAS, shows that a population of cells of the immune system, γδ T cells, could have an important effect in human papillomavirus-induced (HPV) cervical cancer, the third leading cause of cancer death in women.
Christina Schmidt (Cyclotron Research Center) has just been selected to receive an ERC Starting Grant from the European Research Council. This grant (around 1.5 million Euros), was awarded to pursue research that explores the link between circadian regulation of the sleep-wake cycle and cognitive aging. Congratulations!
Anouk Georges (Laurent Nguyen's lab) received a 15000€ prize of the Fondation Roi Baudouin (Fund John W. Mouton Pro Retina) for their project "Support for 'Modulating synaptogenesis in mouse iPS-derived 3D retinal cultures: a strategy to enhance neural circuit reconstruction post-transplantation".
A few months after the discovery of a novel mechanism by which viruses cause leukemia ,the research team led by Anne Van den Broeke publishes a new study in which the researchers apply an optimized molecular method to monitor disease progression in patients. They show that the new method enables a better evaluation of the therapeutic response for this particularly aggressive type of leukemia.
In association with the GIGA Imaging Platform, we propose to provide specific training sessions. These sessions will be provided at the GIGA center on the 7th and 8th of september during lunchtime from 12 to 14 PM.
The team of François Jouret, (FNRS) researcher at GIGA and nephrologist at the CHU in Liège, is working on the use of PET-scan at 18FDG in the non-invasive diagnosis of acute rejection of the renal graft. This approach, developed in collaboration with the Nuclear Medicine Department of the CHU in Liège (Prof. Roland Hustinx, Dr Pierre Lovinfosse), would avoid an unnecessary renal biopsy in many renal transplant recipients.
A new article published by Dr. Malgrange's team (GIGA-Neurosciences) reveals a new function of microRNAs (miRNAs). It suggests that miRNAs play a major role in the development of the auditory portion of the inner ear.
Christina Schmidt is a researcher at GIGA-CRC In vivo Imaging. His research theme focuses on the link between cognition and sleep with a chronobiological approach through circadian rhythms. She is particularly interested in cognitive aging in this approach. She has just obtained a mandate as a Research Associate from the FNRS.
The projects of Fabrice Bureau, Pierre Close and Thomas Marichal have been selected for this 4th call for projects WELBIO, whose mission is to support the fundamental research of excellence in life sciences in Wallonia. Congratulations to them!
Scientists have closed in on specific genes responsible for Inflammatory Bowel Disease (IBD) from a list of over 600 genes that were suspects for the disease. The team from the Wellcome Trust Sanger Institute and their collaborators at the Broad Institute of MIT and Harvard and the GIGA Institute of the University of Liège combined efforts to produce a high resolution map to investigate which genetic variants have a causal role in the disease.
Le Conseil d'Administration du FNRS a dévoilé hier la liste des nouveaux mandats octroyés. Félicitations à tous les chercheurs sélectionnés !
The GIGA Cell Imaging Platform is proud to announce that the beautifull brand new lightsheet Z1 microscope is well arrived and already installed within the Core facility.
The "prix Galien de Pharmacologie" is organized each year in Belgium by the "Journal du Médecin". It awards a work in fundamental or clinical Pharmacology that has been accomplished by a researcher or a team of researchers below the age of 40. The Prix Galien de Pharmacologie 2016 (awarded in 2017) was awarded to Julien Hanson for his contribution to the study of understudied G protein coupled receptors.
This prize confirms the value of the project of PDC*Line Pharma. It's attribuated by academic Key Opinion Leaders in oncology from the largest research institutes in Europe and international leaders of R&D Oncology departments from MATWIN's partner pharmaceutical companies.
A team of researchers led by Anne Van den Broeke (GIGA-ULg and Institut Jules Bordet-ULB) has uncovered a novel mechanism by which viruses cause leukemia. These new findings, published on 23rd May in Nature Communications, could be key to the understanding of virus induced cancers and the development of targeted therapeutic strategies for a very aggressive type of leukemia.
GIGA joins the University of Liège and CHU of Liège to send their warm congratulations to Steven Laureys, the Prix Francqui 2017, the most prestigious Belgian scientific prize. Congratulations !
The teams of Pierre Close and Alain Chariot (GIGA-Molecular Biology of Diseases) publish an article in Trends in Cancer where they suggest that a new family of enzymes that regulate tRNA modifications could represent targets of New class of inhibitors to be used alone or in combination with existing drugs to better treatment.
Their team has just been rewarded for 2017-2019 for the study of deciphering the role of protein ubiquitination in human cortical malformation and hearing impairment
Researchers at GIGA at the University of Liège and Imperial College in London are discovering how the rhinovirus, the agent responsible for the common cold, acts on our immune system to induce severe exacerbations of asthma in people suffering from this disease.
The team of Bernard Peers has published in BMC Biology an article who demonstrates that transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes.
Thanks to funding from the ERDF, Agnès Noël's team has just acquired the Micron IV from Phoenix Research Labs, which is unique in Europe. This equipment will help research related to Age-related Macular Degeneration (AMD), a major cause of blindness among people over 65 years.
The team of Fabrice Bureau and Thomas Marichal of GIGA discovers how exposure to microbes protects against asthma and propose a cell therapy approach that can lead to novel treatments for the disease
The SBN mentioned: "Dr. Balthazart embodies the spirit and inspiration of Danny Lehrman, with a career of eminent scholarship and a record of outstanding mentorship of future scientists".
La société Clarity Pharmaceuticals est une entreprise fondée voici une demi-douzaine d'années qui travaille dans le secteur de la médecine nucléaire, plus précisément dans le domaine de l'imagerie. Elle a mis au point une molécule qui permet de diagnostiquer des maladies cardio-vasculaires.
The Gertrud Reenmtsma Foundation (Max Planck Society) has just named its winners in the category of fundamental research in neurology. Steven Laureys (Coma Science Group - GIGA-Consciousness) shares the "Klaus Joachim Zülch" Prize 2017 with Giulio Tononi (University Wisconsin-Madison). The two researchers are rewarded for their "fundamental discoveries in the neurology of consciousness and coma".
The team of Michaël Herfs (laboratory of Experimental Pathology - GIGA Cancer) published an article in The Journal of Pathology which highlights the existence of 2 subtypes of anal squamous cell carcinoma and the prognostic significance of tumor origin in patients treated for HPV-positive cancer.
The GIGA has been recently awarded with an European grant from the 4th call of the Infect-Era. The laboratory of Emmanuel Dejardin, together with research groups from France and Germany, is involved in a project called Target-HDV. The goal of this project is to better understand the HDV (Hepatitis Delta Virus) in order to cure it.
The next GIGA Day will be held on February 1st. It's organized by the GIGA-Cancer unit and will be about "new insights into the new hallmarks of cancer". Have a look on the program and don't forget to register before January, 22nd !
As of January 1st, PDC*line Pharma has settled in at the GIGA « labhotel ». The spin-off, created in 2014 in Grenoble has moved to Belgium and chose GIGA to launch its activities regarding the development of a new class of immunotherapy based on the universal and powerful line of cells showing antigens, that can be loaded with various types of target tumoral antigens.
We wish you a wonderful year !
The GIGA Flow Cytometry core facility acquired a new flow cytometer analyzer, the BD LSR Fortessa equipped with a High Throughput Sampler (HTS) module. This FACS delivers the optimal sensitivity and resolution required for multicolor applications since it can be used to detect 18 colors simultaneously thanks to the 5 laser lines that it supports.
Khalil Farhat, PhD student in the laboratory of Immuno-Endocrinology (GIGA-I3) has been selected as the best poster in the category "Infectious diseases and Immunology" by the scientific committee of the SFI (Société Française d'Immunologie), which celebrated its 50th anniversary this year in Paris.
Michel Georges, director of GIGA, talks about the imminent transition of genomic medicine and how to better benefit from research grants from Europe. Interviews to find in the supplement of "La Libre" of November 30 or on the website www.innover.be.
The Metastasis Research Laboratory team (LRM, GIGA-Cancer) published an article in the journal eLife demonstrating the pro-cancer effect of methylglyoxal via glycation of Hsp90 and accumulation YAP factor transcription.
In a study plublished in The Journal of Clinical Investigation, the team of Thomas Marichal (GIGA-I3, Immunology Laboratory of Cellular and Molecular, Pr. Fabrice Bureau), in collaboration with the team of Steve Galli (University of Stanford, California), discovered an important role of a protein, called guanine nucleotide exchange factor RAB-1 (RABGEF1) in maintaining epithelial skin homeostasis and prevention of atopic dermatitis.
A team from the Cyclotron (GIGA-CRC In Vivo Imaging) published results in the journal Cortex demonstrating metacognition deficit in Alzheimer's patients is linked to a loss of gray matter volume at the lower lateral prefrontal cortex.
This Friday was held the "Board of Counselors" at GIGA where academic and scientific world experts were invited to give their views on the GIGA strategic plan.
The European Union, through the Horizon 2020 programme, is investing €45 million in research to combat the outbreak of the Zika virus disease and other emerging infections transmitted by mosquitoes. The laboratory of Laurent Nguyen (GIGA-Neurosciences) is part of the ZikAlliance consortium in the aim to understand cellular and molecular mechanisms of microcephaly induced by Zika in fetuses.
On 28/09, the European Commission and Parliament launched the 2016 European Researchers' Night at the European Parliament. Delphine Franssen (GIGA-Neurosciences) won the 2nd prize with her presentation "When the environment controls puberty".
The second Coma European Day about coma and consciousness disorders will be held at Liège by the Coma Science Group on Tuesday, November 8th. Program: Conference from Steven Laureys, testimonials, debates, projection and concert.
The team of Pierre Close and Alain Chariot published an article in the "Journal of Experimental Medicine" demonstrating the influence of ELP3 and CTU1 / 2 in the development of metastasic breast cancers. The inhibition of these enzymes may provide a novel pharmacological approach for the treatment of these cancers.
A new article published in Cell research by Laurent Nguyen's team (GIGA-Neurosciences) demonstrate that Elongator cell-autonomously promotes cortical interneuron migration by controlling actin cytoskeletal dynamics.
Two fundamental research articles of the Animal Genomics Laboratory (GIGA-Medical Genomics) on the genetic analysis of cattle populations has just been published in Genome Research. The first article focuses on the identification of coding variants associated with major effects on the recombination rate in cattle. The second study found, thanks to genome sequencing of many cattle, lethal recessive mutations for the embryo.
Long considered as a "useless" organ, the thymus is now recognized as playing a vital role in our immune system. In a book published by "Presses Universitaires de Liège", Vincent Geenen (GIGA-I3) talk about this gland for which he has become a global specialist.
Through donations and bequests, the aim of Leon Fredericq Fund is to "give to the intelligence and creativity of young researchers the means to serve the scientific understanding and medical progress." Each year, the fund subsidizes a large number of GIGA researchers and researchers from the CHU of Liège.
Although the connection between RNA synthesis and decay has been known to scientists for some years now, the actual protein that connects the two processes had remained unknown until very recently.
The work entitled “The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools” by Maximiliano Figueroa et al, has been selected as the cover after been accepted in the Journal of Structural Biology.
The eosinophils that contribute to inflammation and exacerbation of the asthmatic response had been known to scientists for some time. But another type of eosinophil has been discovered that, to the great surprise of Researchers at the University of Liege’s GIGA research centre, has been shown to play a protective and beneficial role. Their astonishing discovery is published in The Journal of Clinical Investigation.
The latest measures by functional imaging confirmed that brain performance depends at any time of the sleep debt but also our circadian clock, with 24-hour cycles. Results are published in the journal Science by researchers from GIGA.
Research based on the work of Morgane Bourcy and Christine Gilles'team from the laboratory of Tumor and Development Biology (GIGA-Cancer) make the cover of the journal "Cancer Research" (July item) with a publication related to the high potential metastatic of derived circulating tumor cells from epithelial-mesenchymal transition.
In the wake of previous work carried out on a group of proteins called Elongator, a team of researchers from Liège, led by Dr. Laurent Nguyen discovered a signaling pathway that plays an important role at various stages of cortical development. Exacerbation of this pathway may lead to underdevelopment of the brain and cerebral cortex in particular. This find is very promising, including, why not, for the development of a future therapy to counter the microcephaly (an article FNRS News).
2 articles in the FNRS News of June show how the zebrafishes can be useful in totally different fields of research... Examples of research conducted by Marc Muller, of the laboratory of Organogenesis and Regeneration.
Initially recognized as homeostatic signalling pathway that helps cells to cope with cellular stress, the Unfolded Protein Response (UPR) has kept an unexpected activity well hidden up until now. It would also seem that it plays an important physiological role in the development of the nervous system. That's what Laurent Nguyen and his team reveal in an article published in Trends in Neurosciences.
Le FNRS vient d'attribuer ce vendredi ses nouveaux mandats. Les candidatures de 24 chercheurs du GIGA ont été retenues pour les différents mandats. Félicitations à tous et plus particulièrement encore à Thomas Marichal, qui se voit nommé à un poste de chercheur qualifié.
A GIGA team, in collaboration with Italian, English and americans researchers, showed that the responsiveness of neurons control was one of the means used by the body clock to maintain our cognitive functioning. This discovery, published this week in Nature Communications, shows that even the simplest aspects of brain function are affected by our circadian clock, with moments of lesser reactivity or exacerbated reactivity of neurons.
In 2015, EFSA (European Food Safety Authority) has fixed the daily dose "safe" to health to 4 mg / kg of bisphenol-A (BPA). A study of the GIGA-Neuroscience has demonstrated that two weeks of exposure newborns raccoons at a dose 160 times lower than that threshold sufficient to disrupt an essential neurotransmitter system in the brain.
The team of Julie Bakker recently published in "The Journal of Clinical Endocrinology & Metabolism" a research article focuses on the expression of kisspeptin in humans. The results of their study confirm that there are significant gender differences and that women have more neurons in kisspeptin than men. Moreover, transsexuals have an expression similar to that of women when there is no difference among homosexuals. It also appears that the number of kisspeptin neurons is higher in children (especially before puberty) and in older people, bringing new questions and opening new avenues of research still little explored.
Researchers from Franck Dequiedt's lab (GIGA-Molecular Biology of Diseases) in collaboration with ULB and American researchers have published findings in the journal Nature Structural & Molecular Biology which show the conductor role of transciption factors, as these proteins seem to regulate all the steps of gene expression. This important discovery in biology opens new prospects for medical research, including some cancers.
Formerly known as Scinnamic, the company “Bridge 2 Health” has just changed its name, reflecting its ambitions and objectives: building bridges with the healthcare sector. CHU de Liège and ULg have empowered Bridge 2 Health (B2H) to boost exploration of new partnerships with industry and research institutes worldwide focusing on Neurology, Oncology, Cardiology and Bone and Cartilage.
In addition to those usually offered, 3 new fellowships are available within the call for applications of the Fonds Léon Fredericq 2016-2017.