56
Examples of publications including
results partly obtained thanks to the
GIGA-Proteomics platform
Ait-Belkacem R, Sellami L, Villard C, Depauw
E, Calligaris D, Laftte D. Mass spectrometry
imaging is moving toward drug protein co-lo-
calization. Trends Biotechnol 2012;30:466-74.
Collodoro M, Lemaire P, Eppe G, Bertrand V,
Dobson R, Mazzucchelli G, Widart J, De Pauw
E, De Pauw-Gillet MC. Identifcation and
quantifcation of concentration-dependent
biomarkers in MCF-7/BOS cells exposed to
17beta-estradiol by 2-D DIGE and label-free
proteomics. J Proteomics 2012;75:4555-69.
Dumont B, Castronovo V, Peulen O, Bletard N,
Clezardin P, Delvenne P, De Pauw EA, Turtoi
A, Bellahcene A. Diferential proteomic ana-
lysis of a human breast tumor and its matched
bone metastasis identifes cell membrane and
extracellular proteins associated with bone
metastasis. J Proteome Res 2012;11:2247-60.
Henrotin Y, Gharbi M, Mazzucchelli G, Dubuc
JE, De Pauw E, Deberg M. Fibulin 3 peptides
Fib3-1 and Fib3-2 are potential biomarkers of
osteoarthritis. Arthritis Rheum 2012;64:2260-7.
1304
MALDI-TOF protein
identifcations
453
LC-MSMS protein digest
identifcations
150
Mass determinations by
FT-MS or ESI-Q-TOF-MS
23
Multidigestions for maximum
sequence coverage of
pure protein
96
Label free quantitative
diferential proteomic
analyses (nano UPLC-Synapt
HDMS Waters)
6
2-D gels experiments
Proteomics
The proteomics platform ofers a broad range of services, mostly based on mass spectrometry. It also
continously develops new applications in collaboration with the Laboratory of Mass Spectometry and
with diferent research groups.
One of the technics that is actually developed and optimized within the platform, is the Mass spectro-
metry Imaging, that certainly opens new perspectives for biomarkers or drugs discovery.
The agreement for the Federal Agency for Medecine and Health Products makes the platform a good
partner for the private sector.
Contacts
Dominique Baiwir
Gabriel Mazzucchelli
Nicolas Smargiasso
proteomics.giga@ulg.ac.be
www.giga.ulg.ac.be/proteomics
Services