GIGA 2021 Annual Report 47 SELECTED PUBLICATIONS Regular dietary intake of palmitate causes vascular and valvular calcification in a rabbit model. Donis N, Jiang Z, D’Emal C, Dulgheru R, Giera M, Blomberg N, Delvenne P, Nchimi A, Lancellotti P, Oury C. Front Cardiovasc Med 2021; 8:692184 Cancer and cardiovascular mortality risk: is the die cast? Lancellotti P, Nguyen Trung M-L, Oury C, Moonen M. Eur Heart J 2021; 42:110-112 mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy. Schlingmann KP*, Jouret F*, Shen K*, Nigam A, Arjona FJ, Dafinger C, Houillier P, Jones DP, Kleinerüschkamp F, Oh J, Godefroid N, Eltan M, Güran T, Burtey S, Parotte MC, König J, Braun A, Bos C, Ibars Serra M, Rehmann H, Zwartkruis FJT, Renkema KY, Klingel K, Schulze-Bahr E, Schermer B, Bergmann C, Altmüller J, Thiele H, Beck BB, Dahan K, Sabatini D, Liebau MC, Vargas-Poussou R, Knoers NVAM, Konrad M, de Baaij JHF. J Am Soc Nephrol. 2021;32:2885-2899. [18F]FDG PET/CT imaging disproves renal allograft acute rejection in kidney transplant recipients with acute kidney dysfunction: a validation cohort. Lovinfosse P, Weekers L, Pottel H, Bouquegneau A, Bonvoisin C, Bovy C, Grosch S, Hustinx R, Jouret F. Eur J Nucl Med Mol Imaging. 2021; 49: 331-335. Protocol design for the evaluation of chronic antioxidant supplementation on oxidative stress and cognition status in post COVID-19 patients. Bardinet J, Pourtau L, Rousseau AF, Cheramy-Bien JP, Defraigne JO, Pincemail J. Free Radic Biol Med 2021; 177: S119. Myocardial Expression of Estrogen Receptor-mRNA Is Associated With Lower Markers of Post-operative Organ Damage in Young Patients With Congenital Cardiac Defect. Rouatbi H, Farhat N, Heying R, Vazquez-Jimenez JF, Parent A-S and Seghaye M-C. Front Pediatr 2021; 9:729198. KIDNEY DAMAGE IN COVID-19 COVID-19 is a new virus disease that affects many organs in addition to the lungs. Early descriptions of the disease mentioned frequent renal involvement characterized by acute renal failure and the presence of protein (proteinuria) and/or blood (hematuria)1. The mechanisms of this renal damage remain debated. A direct aggression of the renal cells by the SARS-Cov-2 virus has been suggested. However, other factors, such as sepsis, renal hypoperfusion or the administration of nephrotoxic drugs, probably contribute to the renal damage1. With the support of the FNRS, we quantified and characterized COVID-19-associated proteinuria to assess its short-term prognostic role2. We also studied the evolution of this proteinuria in the medium term3. In our cohort of ~150 patients, proteinuria was detected in ≥80% of patients. This proteinuria was mainly of tubular origin. When even this proteinuria was not systematically associated with acute renal failure, a significant association was objectified between proteinuria and mortality2. Among COVID-19 survivors who were systematically followed up (~75 patients), a quasi-normalization of proteinuria was observed at ~2 months post-hospitalization3,4. In parallel to this clinical study, we described the renal histological involvement of COVID-19 by performing postmortem renal biopsy in ~15 patients who died of COVID-19. Lesions of acute tubular necrosis were predominantly found, associated with a «congestive» accumulation of red blood cells in the glomerular and peri-tubular capillaries5. SARS-CoV-2 has been detected in the nephron by different methods, such as immunohistochemistry and in situ hybridization. We are continuing our investigations to better understand how SARS-CoV-2 virus causes such tubular proteinuria and/ or acute tubular necrosis in order to improve the management of any patient with COVID-19 and ensure the best follow-up. This work is the result of a multidisciplinary and international collaboration between various clinical services of the University Hospital of Liege and several research laboratories of the GIGA-ULIEGE center. 1. Erpicum P, et al. Atteintes rénales de la COVID-19. Rev Med Liege 75: 109-114, 2020. 2. Huart J, et al. Proteinuria in COVID-19: prevalence, characterization and prognostic role. J Nephrol 34: 355-64, 2021. 3. Antoine Bouquegneau, et al. Patients with COVID-19 mostly recover from tubular proteinuria and acute kidney injuryafter hospital discharge. J Nephrol 34: 967-9, 2021. 4. Long-term effects of COVID-19 on kidney function. Delanaye P, Huart J, Bouquegneau A, Jouret F. Lancet. 2021; 397: 1807. 5. Antoine Bouquegneau, et al. COVID-19-associated nephropathy includes tubular necrosis and capillary congestion, with evidence of SARS-CoV-2 in the nephron. Kidney360 2021; 2:639-652.
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