GIGA 2021 Annual Report 53 SELECTED PUBLICATIONS Loss of the Transfer RNA Wobble Uridine-Modifying Enzyme Elp3 Delays T Cell Cycle Entry and Impairs T Follicular Helper Cell Responses through Deregulation of Atf4. Lemaitre P, Bai Q, Legrand C, Chariot A, Close P, Bureau F, Desmet CJ. J Immunol. 2021 Mar 1;206(5):1077-1087. New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases. de Seny D, Baiwir D, Bianchi E, Cobraiville G, Deroyer C, Poulet C, Malaise O, Paulissen G, Kaiser MJ, Hauzeur JP, Mazzucchelli G, Delvenne P, Malaise M. Int J Mol Sci. 2021, 2021 Dec 31;23(1):434. A Blood Exosomal miRNA Signature in Acute Respiratory Distress Syndrome. Parzibut G, Henket M, Moermans C, Struman I, Louis E, Malaise M, Louis R, Misset B, Njock MS, Guiot J. Front Mol Biosci. 2021 Jul 15;8:640042. Modulation of αVβ6 integrin in osteoarthritis-related synovitis and the interaction with VTN(381-397 a.a.) competing for TGF-β1 activation. Ciregia F, Deroyer C, Cobraiville G, Plener Z, Malaise O, Gillet P, Fillet M, Malaise MG, de Seny D. Exp Mol Med. 2021 Feb;53(2):210222. A Cross-Sectional and Longitudinal Study to Define Alarmins and A-SAA Variants as Companion Markers in Early Rheumatoid Arthritis. Ciregia F, Nys G, Cobraiville G, Badot V, Di Romana S, Sidiras P, Sokolova T, Durez P, Fillet M, Malaise MG, de Seny D. Front Immunol. 2021 Aug 20;12:638814. Identification and Quantitation of Neutrophil Extracellular Traps in Human Tissue Sections. Radermecker C, Hego A, Delvenne P, Marichal T. Bio Protoc. 2021 Sep 20;11(18):e4159. POTENTIAL ROLE OF EPITHELIAL ENDOPLASMIC RETICULUM STRESS AND ANTERIOR GRADIENT PROTEIN 2 HOMOLOGUE IN CROHN’S DISEASE FIBROSIS Collaboration between clinicians and researchers enriches research and ensures the adequacy between fundamental research and the questions raised by clinical activities. This collaboration is at the heart of the activity of the GIGA I3 with most of the teams bringing together clinicians and researchers. In addition, the proximity of the University Hospital of Liège to which the GIGA is attached facilitates access to well-characterized patient cohorts, while access to technological platforms and cutting-edge technologies are decisive for addressing molecular aspects. The gastroenterology laboratory, whose work focuses on the molecular mechanisms underlying Crohn’s disease, participates in this dynamic. It recently demonstrated that secretion of the anterior gradient protein 2 homolog by the epithelium of CD ileal fibrous stenoses may play a role in myofibroblastic differentiation, paving the way for the discovery of new therapeutic approaches for CD patients. with stenosis. Such work illustrates the complementarity and richness of collaborations between fundamental researchers and clinicians. Potential Role of Epithelial Endoplasmic Reticulum Stress and Anterior Gradient Protein 2 Homologue in Crohn’s Disease Fibrosis. Vieujean S, Hu S, Bequet E, Salee C, Massot C, Bletard N, Pierre N, Quesada Calvo F, Baiwir D, Mazzucchelli G, De Pauw E, Coimbra Marques C, Delvenne P, Rieder F, Louis E, Meuwis MA. J Crohns Colitis. 2021 Oct 7;15(10):1737-1750.
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