GIGA 2021 Annual Report 55 SELECTED PUBLICATIONS Insulin sensitivity in critically ill patients: are women more insulin resistant? Uyttendaele V, Chase JG, Knopp JL, Gottlieb R, Shaw GM, Desaive T. Ann Intensive Care. 2021 Jan 21;11(1):12. Virtual patients for mechanical ventilation in the intensive care unit. Zhou C, Chase JG, Knopp J, Sun Q, Tawhai M, Möller K, Heines SJ, Bergmans DC, Shaw GM, Desaive T. Comput Methods Programs Biomed. 2021 Feb;199:105912. Is Mortality Rate of Ventilated Patients With Coronavirus Disease 2019 So High? Lambermont B, Huart J, Chase JG, Delanaye P. Crit Care Med. 2021 Jul 1;49(7):e738-e739. Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels. Reina-Romo E, Mandal S, Amorim P, Bloemen V, Ferraris E, Geris L. Front Bioeng Biotechnol. 2021 Aug 6;9:701778. Turning Nature’s own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering. Papantoniou I, Nilsson Hall G, Loverdou N, Lesage R, Herpelinck T, Mendes L, Geris L. . Adv Drug Deliv Rev. 2021 Feb;169:22-39. Lommers E, Guillemin C, Reuter G, Fouarge E, Delrue G, Collette F, Degueldre C, Balteau E, Maquet P, Phillips C. VoxelBased quantitative MRI reveals spatial patterns of grey matter alteration in multiple sclerosis. Hum Brain Mapp. 2021 Mar;42(4):1003-1012. ENHANCING BONE REGENERATION USING COMPUTER MODELING AND 3D PRINTING The loss of one or more teeth, usually due to trauma or infection, can lead to functional (chewing) or social difficulties. The treatment of choice is to replace the lost tooth with a dental implant. However, in order to be permanent, the placement of implants requires a sufficiently large volume of bone to present. As the loss of a tooth results in bone loss, regeneration of the alveolar bone is a necessary step before the implants can be placed. Clinicians specialized in implantolog use bone substitute biomaterials as a basis to guide bone regeneration. Many such biomaterials exist, both from natural and synthetic origin, but effective regeneration of the entire volume remains a challenge due to suboptimal physico-chemical properties of the materials. There is a growing interest in synthetic bone regeneration biomaterials with a customized three-dimensional (3D) shape, perfectly adapted to the patient’s bone defect – which was also the aim of the BIOPTOS project. The clinical expertise came from the d-BRU team (Prof. France Lambert & Dr. Dorien Vanhede) of the CHU Liège / U.Liège, while the team of Prof. Liesbet Geris (GIGA In Silico Medicine) was responsible for developing the computer model used to optimize the internal design of the 3D printed biomaterial. In order to build the computer model, basic biological knowledge on cell and tissue growth was translated into mathematical equations and calibrated using dedicated in vitro experiments. Subsequently, it was used to compare (simulated) neotissue formation inside 3D porous structures, taking into account manufacturing limitations, to find the optimal internal architecture. In vivo experiments in a standard alveolar bone regeneration model demonstrated the superiority of the developed biomaterial over the current clinical gold standard. These results have been published in Advanced Functional Materials, with Prof. Lambert and Geris sharing senior authorship, illustrating the significant contributions made to this study from both the engineering and clinical side. 3D-Printed Synthetic Hydroxyapatite Scaffold With In Silico Optimized Macrostructure Enhances Bone Formation In Vivo. Van hede D, Liang B, Anania S, Barzegari M, Verlée B, Nolens G, Pirson J, Geris L, Lambert F.Adv Funct Mater. 2021 October, vol 32, 2105002.
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