GIGA 2021 Annual Report 57 SELECTED PUBLICATIONS PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads. Artesi M, Hahaut V, Cole B, Lambrechts L, Ashrafi F, Marçais A, Hermine O, Griebel P, Arsic N, van der Meer F, Burny A, Bron D, Bianchi E, Delvenne P, Bours V, Charlier C, Georges M, Vandekerckhove L, Van den Broeke A, Durkin K. Genome Biol. 2021 Apr 6;22(1):97. Novel EDGE encoding method enhances ability to identify genetic interactions. Hall MA, Wallace J, Lucas AM, Bradford Y, Verma SS, Müller-Myhsok B, Passero K, Zhou J, McGuigan J, Jiang B, Pendergrass SA, Zhang Y, Peissig P, Brilliant M, Sleiman P, Hakonarson H, Harley JB, Kiryluk K, Van Steen K*, Moore JH*, Ritchie MD*. PLoS Genet. 2021 Jun 4;17(6):e1009534. * These authors are joint senior authors on this work A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle. Lee YL, Takeda H, Costa Monteiro Moreira G, Karim L, Mullaart E, Coppieters W; GplusE consortium, Appeltant R, Veerkamp RF, Groenen MAM, Georges M, Bosse M, Druet T, Bouwman AC, Charlier C. PLoS Genet. 2021 Jul 21;17(7):e1009331. MAPPING OF THE HUMAN GENETIC ARCHITECTURE OF COVID-19 In March 2020, thousands of scientists around the world decided to join forces to answer an urgent and complex question: what genetic factors cause some patients with COVID-19 to develop a severe, life-threatening disease requiring hospitalization, while others get by with mild or no symptoms? This question has been answered in a large-scale study conducted by the COVID-19 Host Genetics Initiative consortium (https://www.covid19hg.org), launched by Mark Daly, a longstanding UAG collaborator, Director of the Finnish Institute of Molecular Medicine (FIMM) at the University of Helsinki and core member of the Broad Institute and by Andrea Ganna, Group Leader at FIMM. The GIGA-Research Institute and the CHU of Liege were invited to participate, together with more than 3,500 researchers and physicians from around the world. About sixty researchers and doctors from GIGA, the CHU of Liège and the CHC Mont Légia were quickly mobilised. A unique COVID-19 human body material collection was established and is available to the scientific community through the institutional biobank of the CHU of Liege (BHUL). The results have been published in Nature. The study revealed that 13 loci are strongly associated with the infection or with the development of severe forms of COVID-19. This effort represents one of the largest genome-wide association studies ever conducted to date and included almost 50,000 patients with COVID-19 and two million uninfected «control» individuals. These results will help to provide targets for future therapies and illustrate the power of genetic studies to learn more about infectious diseases. Funding : Walloon region, Léon Fredericq Foundation and FNRS. Contributions ULiège | CHU de Liège GIGA - ULiège Souad Rahmouni, Yves Beguin, Michel Georges, Edouard Louis, Samira Azarzar, Catherine Moermans, Sofia Melo, Nicolas Jacques, Emmanuel Di Valentin, François Giroule, Alice Collignon, Coraline Radermecker, Marielle Lebrun, Alice Collignon, Hélène Perée, Samuel Latour, Olivia Barada, Judit Sanchez, Claire Josse, Bouchra Boujemla, Margot Meunier, Emeline Mariavelle, Sandy Anania, Hélène Gazon, Monique Henket, Myriam Mni, Marie Wéry, Alicia Staderoli, Yasmine Belhaj CHU de Liège Gilles Darcis, Michel Moutschen, Benoit Misset, Julien Guiot, Patricia Dellot, Stéphanie Gofflot, Axelle Bertrand, Gilles Parzibut, Mathilde Clarinval, Olivier Malaise, Kamilia El Kandoussi, Raphaël Thonon, Pascale Huynen, Alyssia Mesdagh, Danusia Juszczak, Marjorie Fadeur, Séverine Camby, Christelle Meuris, Marie Thys, Jessica Jacques, Philippe Léonard, Frederic Frippiat, Jean-Baptiste Giot, Anne-Sophie Sauvage, Christian Von Frenckell, Bernard Lambermont Mapping the human genetic architecture of COVID-19. COVID-19 Host Genetics Initiative. Nature. 2021 Dec;600(7889):472477.
RkJQdWJsaXNoZXIy MTk1ODY=