74 GIGA 2021 Annual Report TEAM Tiffany Di Salvo Platform Expert Hülya Kocadag Platform Expert www. gigaimmunohisto. uliege.be KEY FIGURES 3831 Paraffin embeding 11548 Paraffin section 3832 HE staining 2364 Immunostaining 111 Treatment hard tissues 3420 Scans 40 Research groups 4 Companies MANAGER Chantal HUMBLET chantal.humblet @uliege.be GIGA-IMMUNOHISTOLOGY SOME PRACTICAL IMPLEMENTATIONS LABORATORY OF CARDIOLOGY The platform was brought in the context of a model of heart valve disease and atherosclerosis in rabbits to develop cutting and staining techniques to quantify the areas calcified or not within the heart valves, aorta and heart. The HE, Alizarin red, sirius red, pentachrome and Von Kossa stains used during this collaboration have contributed to three publications: *Oury C et al. Dexfenfluramine and Pergolide Cause Heart Valve Diseasz via Valve Metabolic Reprogramming and Ongoing Matrix Remodeling. Int J MOl Sci, 2020 *Donis N et al. Regular dietary intake of Palmitate Causes vascular and Valvular Calcification. Frontiers cardiovasc Med, 2021 *Donis et al. Differential biological effects of dietary lipids and irradiation on aorta, aortic valve and mitral valve. Frontiers Cardiovascular Med, 2022
RkJQdWJsaXNoZXIy MTk1ODY=