2025 GIGA Annual Report | 13 Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor survival rates due to late diagnosis and lack of effective treatments. In this study, researchers from the Laboratory of Metastases Research, led by Olivier Peulen, investigated myoferlin, an oncoprotein overexpressed in PDAC, to understand its role in cancer cell behavior and mitochondrial dynamics. Using two PDAC cell lines (Panc-1 and MiaPaCa-2), the team explored myoferlin localization, its presence in mitochondria-associated membranes, and its role in mitochondrial calcium transfer. Results indicated that myoferlin is part of mitochondria- associated membranes and its silencing reduces mitochondrial calcium levels upon stimulation, likely through its interaction with inositol 1,4,5-triphosphate receptors. This work sheds light on myoferlin’s involvement in cancer biology and mitochondrial dynamics, offering insights into potential therapeutic targets. IDENTIFICATION OF MYOFERLIN AS A MITOCHONDRIA-ASSOCIATED MEMBRANES COMPONENT REQUIRED FOR CALCIUM SIGNALING IN PDAC CELL LINES Anania S, Farnir M, Peiffer R, Boumahd Y, Thiry M, Agirman F, Maloujahmoum N, Bellahcène A, Peulen O. Cell Commun Signal. 2024 Feb 17;22(1):133. doi: 10.1186/s12964-024-01514-z. p LINKS | Publication on ORBI | Olivier Peulen
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