2025 GIGA Annual Report | 15 Awareness of dependence in daily activities plays a significant role in the evolution of neurodegenerative dementias. Christine Bastin, from the Laboratory of Aging & Memory, led a study investigating how participant and caregiver assessments of dependence could predict changes in autonomy over one year. The study included mildly demented participants diagnosed with Alzheimer’s disease (AD, n = 186) and frontotemporal dementia (FTD, n = 29). The research tool assessed dependence in 98 daily activities and caregiver burden. Discrepancy scores between patient and caregiver assessments of dependence were calculated to evaluate awareness. Results showed that FTD patients had lower awareness of dependence than AD patients. Both groups benefited from cognitive rehabilitation, with a 25% decrease in dependence and reduced caregiver burden. In the AD group, both caregiver and participant assessments at baseline were positively correlated with greater dependence after one year, highlighting the importance of both perspectives in understanding the evolution of dementia and the benefit of care. AWARENESS AND COGNITIVE REHABILITATION IN ALZHEIMER’S DISEASE AND FRONTOTEMPORAL DEMENTIA Salmon E, Lekeu F, Quittre A, Godichard V, Olivier C, Wojtasik V, Bastin C. Alzheimers Dement (N Y). 2024 Apr 16;10(2):e12469. doi: 10.1002/trc2.12469. p LINKS | Publication on ORBI | Christine Bastin
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