18 | 2025 GIGA Annual Report Eosinophils play diverse roles in immunity, tissue repair, and metabolism, yet their development remains poorly understood. Christophe Desmet and his team at the Laboratory of Cellular and Molecular Immunology used advanced single-cell techniques to map eosinophil maturation in both mice and humans. Their research challenges long-standing assumptions about Interleukin-5 (IL-5), a key cytokine in eosinophilia. Rather than directly promoting eosinophil maturation, IL-5 prolongs an intermediate phase where eosinophils multiply, thus increasing their numbers. Blocking IL-5, a strategy used in treating eosinophilic diseases like asthma, reduces eosinophilia by preventing this amplification step. The study provides valuable resources and insights into eosinophil biology, paving the way for improved therapeutic strategies. SINGLE-CELL PROTEOMICS AND TRANSCRIPTOMICS CAPTURE EOSINOPHIL DEVELOPMENT AND IDENTIFY THE ROLE OF IL-5 IN THEIR LINEAGE TRANSIT AMPLIFICATION Jorssen J, Van Hulst G, Mollers K, Pujol J, Petrellis G, Baptista AP, Schetters S, Baron F, Caers J, Lambrecht BN, Dewals BG, Bureau F, Desmet CJ p LINKS | News GIGA | Publication on ORBI | Christophe Desmet Immunity. 2024 Jul 9;57(7):1549-1566.e8. doi: 10.1016/j.immuni.2024.04.027.
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