2025 GIGA Annual Report | 27 APOMORPHINE FOR PROLONGED DISORDERS OF CONSCIOUSNESS: A MULTIMODAL OPEN-LABEL STUDY Sanz LRD, Lejeune N, Szymkowicz E, Bonin EAC, Panda R, Sala A, Thibaut A, Huerta-Gutierrez R, Dardenne N, Dikenstein D, Van Goethem S, Ledoux D, Hustinx R, Stender J, Farber NM, Zafonte RD, Schiff ND, Laureys S, Gosseries O. A study led by Leandro Sanz and Olivia Gosseries from the Coma Science Group explores the potential of apomorphine to aid recovery in patients with severe brain injuries and impaired consciousness. Thirteen patients received subcutaneous apomorphine treatment for 30 days, showing significant improvements in behavioral responses, including visual pursuit and command-following, compared to a control group. These gains persisted even after treatment cessation. Using EEG, and PET scans, the researchers found enhanced brain connectivity and metabolism in treated patients. This preliminary study shows promising results for apomorphine in post-coma recovery. While further trials are needed, the study highlights apomorphine as a potential therapeutic for disorders of consciousness. EClinicalMedicine. 2024 Nov 15;78:102925. doi: 10.1016/j.eclinm.2024.102925 p LINKS | News GIGA | Publication on ORBI | Olivia Gosseries
RkJQdWJsaXNoZXIy MTk1ODY=