2025 GIGA Annual Report | 33 Horizon Europe (1) MSCA - Marie Sklodowska-Curie Actions Staff Exchanges DOC-BOX Development of a multimodal toolbox to ensure a fast and reliable diagnosis of consciousness disorders. p Charlotte Martial 225 400 € DoCBox aims to develop a fast and easy-touse toolbox combining behavioral, neuroimaging, and neurophysiological assessments to accurately diagnose patients with disorders of consciousness (DoC). Designed to meet the strict time constraints of clinical settings, this toolbox will improve evaluation and care for this vulnerable population. The project promotes interdisciplinary research and international collaboration to translate and validate tools such as behavioral scales and software pipelines. Its three main goals are: provide new bedside tools to better detect signs of consciousness; identify reliable neurophysiological and neuroimaging biomarkers and develop user-friendly software; and engage both formal and informal caregivers in diagnosis. With 17 partners across Europe and beyond, the consortium aims to deliver guidelines and policy recommendations to enhance DoC diagnosis and care, advancing understanding of consciousness disorders. Horizon Europe (1) MSCA - Marie Sklodowska-Curie Actions Postdoctoral Fellowships TRIQ Searching for TRans-eQTL affecting the risk to develop Inflammatory Bowel Disease p Souad Rahmouni 191 760 € Inflammatory Bowel Disease, including Crohn’s disease and ulcerative colitis, now afflict close to 1/250 individuals in industrialized societies. There is a pressing need for effective preventive means as well as curative drugs. CiseQTL analyses are uncovering a growing list of genes that are perturbed by IBD risk variants detected by GWAS, constituting a list of prime drug targets for the pharmaceutical industry. Cis-eQTL effects trigger downstream effects – both within the same (intracellular) and other cell types(intercellular) – that culminate in disease declaration. Some of these downstream effects are accompanied by changes in transcriptlevels referred to as trans-eQTL effects. The aim of the TRIQ project is to take advantage of the CEDAR-II dataset – transcriptomedata for up to 400 individuals in > 75 IBD-relevant cell types – to identify trans-eQTL effects that mediate IBD predisposition. The genes that are perturbed by these trans-effect will include druggable targets that constitute prime targets for the development of new IBD therapies. Horizon Europe (1) MSCA - Marie Sklodowska-Curie Actions Postdoctoral Fellowships DENOVO Towards an Integrative Model of the Relationship Between Episodic Memory and Novelty Detection Through a Behavioural and Neuropsychological Approach p Christine Bastin 139 270 € DENOVO explores how different types of novelty—absolute (entirely new), contextual (familiar in a new context), and associative (new combinations of known elements)—interact with episodic memory. While novelty is known to support memory encoding, their precise relationship remains unclear. Unlike previous research based mainly on neuroimaging, DENOVO combines behavioral testing, cognitive psychology, and neuropsychology of aging. The project examines whether absolute novelty is directly linked to memory, while the other types may act more independently. Findings could improve understanding of memory mechanisms and inform the diagnosis and management of conditions like amnestic Mild Cognitive Impairment and Alzheimer’s disease.
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