2025 GIGA Annual Report | 37 TÉLÉVIE PLURI-UNIVERSITY RESEARCH PROGRAMS Intestinal cancers, tumor micro-environment and microbiota CHARIOT Alain, LETELLIER-LAMBERTY Elisabeth tRNAs Modifications and Translational Reprogramming in Leukemias-Associated Treg CLOSE Pierre, PAGGETTI Jérôme Metabolic Modulation for Enhanced Anticancer Immunity FERON Olivier, HERFS Michael Viral cancer models and single-cell genomics to study tumor evolution: retrospective tracing of a novel catalogue of tumor-specific somatic alterations in the rare tumor ancestor cell GEORGES Michel, CHARLIER Carole, JESCHKE Jana, VAN DEN BROEKE Anne Investigating formate-induced reprogramming of mRNA translation in lung cancer MEISER Johannes, BLOMME Arnaud PROJECTS RENEWAL Systems biology approaches for comprehensive analyses of immune response to BNT162b2 mRNA and inactivated influenza vaccines in allogeneic hematopoietic stem cell transplant recipients BARON Frédéric Impact of ozone exposure on pulmonary microenvironment and metastatic dissemination CATALDO Didier Importance of transfer RNA editing in colon cancer CLOSE Pierre Characterization of a novel role for FET oncogenic fusions in the regulation of mRNA stability DEQUIEDT Franck Discovery and targeting of tumor-specific antigens presented by diapaused acute myeloid leukemia cells EHX Grégory Inhibition of “second- generation” B7-H3 and CD112 immune checkpoints for the treatment of malignant pleural mesothelioma HERFS Michaël Identification of inhibitors of G proteincoupled receptors to protect against cisplatin-induced ototoxicity MALGRANGE Brigitte Impact of ovarian tissue preservation on future fertility in young cancer patients according to age and chemotherapy dose MUNAUT Carine VE-Cadherin dynamics and interactomics in tumoral lymphangiogenesis NOEL Agnes Study of PTK7 expression and roles in glioblastoma and targeting approaches ROGISTER Bernard Characterization of CXCR4 and ACKR3 receptors in glioblastoma tumor microenvironment ROGISTER Bernard Insights into the role of microRNA-encapsulated endothelial extracellular vesicles in pre-metastatic niche formation and metastasis in breast cancer STRUMAN Ingrid Eosinophils inhibit response to chemotherapy: mechanisms and preclinical investigation in mesothelioma WILLEMS Luc
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