40 | 2025 GIGA Annual Report AWARDS & EVENTS INAUGURAL LECTURE OF THE PRINCESS LILIAN HEART FOUNDATION CHAIR Prof. David Lyden (Weill Cornell Medical College) inaugurated at ULiège in April 2024 the series of lectures and meetings in Belgium on The pre-metastatic nice concept. The University of Liège was delighted to host, for the second time, the inaugural lecture of the chair organised by the Princess Lilian Heart Foundation, which in 2024 welcomed Prof. David Lyden from Weill Cornell Medical College (WCM) in the United States. Professor of Paediatrics and Director of the Cellular Oncology Programme at WCM, David Lyden is internationally renowned for his pioneering research into the pre-metastatic niche and the biology of the exosome in the metastatic process. Prof. David Lyden’s lecture, The pre-metastatic nice concept, was the prelude to a week of lectures and meetings with young researchers at GIGA and after at Belgian, Flemish and French-speaking universities. GRÉGORY FETTWEIS AWARDED BY THE KING BAUDOUIN FOUNDATION This prize, awarded by the King Baudouin Foundation’s fund in pediatric hemato-oncology aims to recognize outstanding basic research projects on the mechanisms of pediatric cancers. The goal is to enhance understanding of the biology of pediatric tumors through studies on genetic alterations, signaling pathways, or the tumor microenvironment. The project In Ewing’s sarcoma, a pediatric cancer caused by a gene fusion, an abnormal transcription factor reprograms gene expression by altering 3D genome architecture. Grégory’s project, Targeting 3D chromatin architecture as a new therapeutic avenue in Ewing Sarcoma, investigates how this DNA reorganization drives tumor development. He also aims to identify small molecules that could inhibit these changes, exploring new therapeutic strategies targeting genome structure.
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