Le mardi 17 décembre 2024, Gustavo GUERRERO LIMON présentera l'examen en vue de l’obtention du grade académique de Docteur en Sciences (Collège de doctorat en Biologie des organismes et écologie) sous la direction de Marie-Louise SCIPPO et Marc MULLER.
Cette épreuve consistera en la défense publique d’une dissertation intitulée :
« Evaluating the effects of endocrine disruptors and mixture on development and gene expression in zebrafish (Danio rerio) ».
Persistent organic pollutants (POPs) and endocrine-disrupting chemicals (EDCs) represent significant environmental and health threats due to their inherent properties such as stability, bioaccumulation, and complex interactions in biological systems. This research work synthesizes the findings from original research publications that investigate the developmental, physiological, and behavioral effects of POP and EDC exposure using zebrafish (Danio rerio) as a model organism. In a nutshell, zebrafish larvae were exposed to a mixture of 29 POPs, at different concentrations based on what was found in the blood of Scandinavian populations, to study the effects of these chemicals on growth, skeletal development, behavior, mitochondrial function, and gene expression. The findings from this research highlights the significant risks posed by exposure to POP mixtures, particularly in terms of skeletal and retinal development, behavior, and endocrine disruption.
The outcome of this research provides critical insights into the molecular mechanisms of POP toxicity, with important implications for environmental risk assessment and public health policy. The collective findings emphasize the importance of considering chemical mixtures rather than individual compounds, as their combined effects seemed to be often more severe and complex.
Le Jury sera composé de :
Mme C. JOAQUIM-JUSTO (Présidente), Mmes et M. L. CONNOLLY (Queen's University Belfast), M. MULLER (Co-promoteur), A.S. PARENT, C. ROUGEOT (Secrétaire), M.-L. SCIPPO (Promotrice), L. VERGAUWEN (Universiteit Antwerpen).
La thèse est intitulée : « Linear numeration systems without a dominant root, alternate base numeration systems, and their links ».
La thèse est intitulée : « Towards the discovery and evolutionary analysis of Nonribosomal Peptide Synthetases (NRPS) within protist lineages ».
La thèse est intitulée : « Variability of Jupiter's aurora, moons, and magnetosphere investigated using advanced data analysis ».
La thèse est intitulée : « Milankovitch Forcing and the Timing and Pacing of Devonian Anoxic Events ».
La thèse est intitulée : « Structural Phase Transitions and Complex Polar Orderings in Oxide Perovskites: Insights and Control from First- and Second-Principles ».
La thèse est intitulée : « Analyse didactique du développement de compétences de modélisation en chimie dans l'enseignement secondaire supérieur ».
