During his PhD at Inserm Unit U460 from 2002 to 2005, Benoit Ho-Tin-Noé studied the mechanisms and consequences of plasminogen activation by smooth muscle cells and neurons. In 2006, he joined the Wagner Lab (Harvard Medical School, Boston) for a 3-year postdoctoral fellowship, during which he initiated a series of studies on the role of platelets in maintaining vascular integrity during inflammatory reactions and within tumors. He was then recruited as a research fellow by INSERM in 2009.  His work since joining INSERM has shown that 1) hemostasis in inflamed organs can be achieved independently of platelet aggregation, 2) ischemic strokes induce an early venous thromboinflammatory response, and 3) smooth muscle cells play a central role in the initiation of angiogenesis and cholesterol crystallization in atheromatous artery walls.

Currently, Benoit Ho-Tin-Noé works for the LVTS (Laboratory for Vascular Translational Science) at Hôpital Bichat. His main research themes are 1) the study of mechanisms for preventing inflammatory bleeding, 2) the study of the role of platelet-leukocyte interactions in the pathophysiology of stroke, and 3) the study of platelet regulation of the tumor microenvironment.