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NATURE COMMUNICATIONS

Wobble transfer RNA modifications optimize dynamic proteome expression

In an article published in Nature Communications, Francesca Rapino & Pierre Close, from the Laboratory of Cancer Signaling (GIGA), discover how the modification of transfer RNAs impacts the dynamics of protein expression.

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Alzheimer's Research Foundation supports three ULiège research projects with 600,000 euros

The Alzheimer's Research Foundation has selected three research projects at the University of Liège for a total of 600,000 euros, out of the 3,200,000 euros granted by the Foundation in Belgium.

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Innovation

Creation of a new spin-off from research conducted at the GIGA

The company CMD-Coat S.A., born from a collaboration between the GIGA (GIGA-Cardiovascular), the CHU (cardiology service) and the ULiège chemistry department, was officially born this 25th March.

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A video game camera to calculate the radiation dose received by a worker

A research project conducted in close collaboration with the SCK-CEN has developed a process that provides a more effective measurement of a worker's radiation level than the traditional dosimeter.

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Journal for ImmunoTherapy of Cancer

Blockade of the multifunctional protein HMGB1 improves cancer immunotherapy

Michael Herfs' team (Lab for Experimental Pathology, GIGA-Cancer) demonstrates the importance of blocking the oxidized form of this protein to reactivate anti-tumor immunity and improve the effectiveness of immune checkpoint inhibitors.

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Solène Dauby, Emilie Lommers and Pierre Maquet, laureates of a Charcot Foundation Prize

A grant that will enable them to study certain mechanisms responsible for the disability induced by multiple sclerosis.

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H2020 project

A brave new world of In Silico Trials kicks off across Europe

GIGA is part of this H2020 project. Liesbet Geris, introduced the OcDefects solution, a computational model to be used for In Silico trials of an Advanced Therapeutic Medicinal Product for the repair of deep osteochondral defect.

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MSCA Individual Fellowship

Arnaud Blomme gets a Skłodowska-Curie Individual Fellowship for his TransMetTOR project

This grant will allow him to continue his research in order to study the role(s) of mTORC2 in mRNA translation and cellular metabolism, in the context of lung cancer development.

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Nature Reviews Endocrinology

Early exposure to endocrine disrupting chemicals impairs brain development

Anne-Simone Parent’s team illustrates the consequences of exposure to these compounds on the neuroendocrine system controlling puberty and reproductive functions in Nature Reviews Endocrinology.

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Trends in Cell Biology

Coordination between molecular transport and local translation in neurons

Laurent Nguyen's team (Laboratory of Molecular Regulation of Neurogenesis - GIGA-Stem Cells) reveals the importance of neuronal transport and local translation processes for the formation and proper functioning of synapses.

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GIGA-I3

The tRNA epitranscriptome may play a regulatory role in immunity and haematopoiesis

This is what Christophe Desmet and his team demonstrate in 2 recent publications (J Immunol and J Exp Med).

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A publication in JCI Insight

First observation of the early link between proteins linked to Alzheimer's disease and their impact on brain function

These results will help researchers to identify at an early stage the people most at risk of developing the disease, well before the first cognitive symptoms appear.

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