Exploring the Impact of Tubulin Post-Translational Modifications in Peripheral Neuropathies
Francesca BARTOLINI - Columbia University Medical Center
Peripheral neuropathies are common disorders that result from nerve damage in the peripheral nervous system. Tubulin post-translational modifications and microtubule stability play multiple roles in sensory neuronal function, including regulation of organelle transport, mitochondrial permeability, organelle/organelle contacts, mechanosensory transduction and channel activities. Therefore, the pleiotropic effects promoted by a perturbed microtubule cytoskeleton represent a key point of vulnerability for neurons and a potential cause of nerve degeneration. In support of this model, we have recently discovered a tubulin-based mechanism in the toxic neuropathy induced by the anti-cancer drug and proteasome inhibitor bortezomib, and that disruption of the α-tubulin acetylation/deacetylation cycle may underlie certain forms of inherited neuropathies in which axonal mitochondrial distribution is affected.
Contact : Laurent Nguyen