60
585
Mouse embryo assays
240
Colonies Housed
5
Translational research
programs
10
mES Injections
10
Lines cryopreservations/
Revitalisation or sanitisations
Examples of publications including
results partly obtained thanks to the
GIGA-Animal Facility platform
Detry O, Gaspar Y, Cheramy-Bien JP, Drion P,
Meurisse M, Defraigne JO. A modifed surgical
model of fulminant hepatic failure in the rat.
J Surg Res 2012.
Lambert F, Leonard A, Drion P, Sourice S, Pilet
P, Rompen E. The efect of collagenated space
flling materials in sinus bone augmentation: a
study in rabbits. Clin Oral Implan Res 2012.
Wallemacq H, Bedoret D, Pujol J, Desmet C,
Drion PV, Farnir F, Mainil J, Lekeux P, Bureau F,
Fievez L. CD40 triggering induces strong
cytotoxic T lymphocyte responses to heat-
killed Staphylococcus aureus immunization
in mice: a new vaccine strategy for staphy-
lococcal mastitis. Vaccine 2012;30:2116-24.
Gridelet V, Tsampalas M, Berndt S, Hagelstein
MT, Charlet-Renard C, Conrath V, Ectors F,
Huge F, Munaut C, Foidart JM, Geenen V, Per-
rier d’Hauterive S. Evidence for cross-talk
between the LH receptor and LH during
implantation in mice. Reprod Fertil Dev
2013;25:511-22.
Mice Facility & Trangenesis
Animal experimental models are of great importance both fundamental and applied research. In funda-
mental research, the animal models allow to place molecular and cellular observations back into their
physiological context. In applied research, mouse models remain a mandatory step to evaluate the
efciency and the toxicity of potential treatments, before going to clinical trials.
Moreover, KO or KI mice constitute a potent tool for deciphering the role of a gene of interest.
It is thus critical for the scientists to have access to an animal facility of high value.
The GIGA animal facility ofers a broad range of (internal and external) services such as housing, manage-
ment of reproduction, imaging, surgery, experimental behavior recording while monitoring carefully the
sanitary status of the housed animals. If needed, experiments can be performed in biosafety level 2 or 3.
Prior any experiment, the experimental protocol has to be approved by the Institutional Animal Care
and Use Committee.
Additionally, quality procedures have been implemented and the GIGAMouse facility which is frequent-
ly audited by external companies works in GLP-like conditions. For this, standard operating procedures
are available as well as a traceability system. GIGA Animal Facility follows the guidelines of the Belgian
legislation regarding mandatory training of people involved on the animals (animal caretakers, technicians
and researchers )
Contact
transgenics.giga@ulg.ac.be
www.giga.ulg.ac.be/mouse