Giga - Annual report 2015

Molding thrombus of an ecmo cannula floating in the right atrium

Morimont P, Lambermont B, Gaspard V, Defraigne JO.

Intensive Care Medicine.

2015;41:1965-1966

This article is a case report of a 23-year-old man was referred to CHU for veno-aerterial extracorporeal membrane oxygenation

(VA ECMO) support as a bridge to heart transplantation.

(tissue pet) vascular metabolic imaging and peripheral plasma biomarkers in the evolution of chronic aortic

dissections

Sakalihasan N, Nienaber CA, Hustinx R, Lovinfosse P, El Hachemi M, Cheramy-Bien JP, Seidel L, Lavigne JP, Quaniers J, Kerstenne

MA, Courtois A, Ooms A, Albert A, Defraigne JO, Michel JB.

European Heart Journal - Cardiovascular Imaging

2015;16:626-633

Despite adequate medical management, dissection of the descending aorta (type B) may develop complications, including

aneurysmal progression and eventually rupture. Partial false lumen thrombosis has been identified as a marker of adverse

evolution in chronic dissection. The aim of this study was to test the ability of complementary information, provided by (18)

F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) and peripheral biomar-

kers, to add pathophysiological significance and a prognostic value to morphological data. We explored serial aortic (18)F-FDG

uptake by PET/CT imaging and plasma biomarkers in a series of 23 patients with type B dissection to predict complications from

initial data and to investigate potential associations with aneurysmal expansion during follow-up. Complications occur-

red in 17 patients. Acute initial characteristics associated with complications were male gender (P = 0.021), arterial hyperten-

sion (P = 0.040), aortic dissection diameter (P = 0.0086), partial thrombosis of the false channel (P = 0.0046), and enhanced

focal (18)F-FDG uptake (P = 0.045). During follow-up (mean 16.7 ± 8.0 months), aneurysmal expansion was associated with false

lumen morphology (P< 0.0001), quantitative (18)F-FDG uptake, (P = 0.0029), elevated plasma concentrations of biomar-

kers of platelets (P-selectin, P = 0.0009) and thrombin activation (TAT complexes, P = 0.0075), and fibrinolysis (PAP complexes,

P < 0.0001; D-dimers, P = 0.0006). Plasma markers of coagulation and fibrinolysis were related to false channel morphology,

suggesting that thrombus biological dynamics may drive progressive expansion of type B dissections. Enhanced FDG uptake may be

considered as a complementary imaging marker associated with secondary complications in type B dissections. During follow-up,

aneurysmal progression is related to PET/CT and biomarkers of thrombus renewal and lysis.

Laboratories

Valvular Heart Disorders

Luc Piérard, Patrizio Lancellotti, Cécile Oury

Thrombosis Hemostasis

CécileOury, Patrizio Lancellotti, AndréGothot

Vascular Wall Disorders

Natzi Sakalihasan, Jean-Olivier Defraigne, Joël

Pincemail

Hemodynamics

Bernard Lambermont, Philippe Kohl,

Vincenzo d’Orio, Alexandre Ghuysen,

Philippe Morimont, Thomas Desaive

Experimental Surgery

Jean-Olivier Defraigne, Pierre Drion,

François Jouret, Jean-Marie Krzesinski,

Olivier Detry

Bioengineering Biophysics

Pierre Dauby, Thomas Desaive

People

15 Scientists

15 Clinician researchers

12 PhD Students

6 Technicians

65%

35%