GIGA - Annual report 2022

26 GIGA-MBD INPP5E controls ciliary localization of phospholipids and the odor response in olfactory sensory neurons. Ukhanov K, Uytingco C, Green W, Zhang L, Schurmans S, Martens JR. J Cell Sci. 2022 Mar 1;135(5):jcs258364. Unveiling the Metal-Dependent Aggregation Properties of the C-terminal Region of Amyloidogenic Intrinsically Disordered Protein Isoforms DPF3b and DPF3a. Leyder T, Mignon J, Mottet D, Michaux C. Int J Mol Sci. 2022 Dec 4;23(23):15291. Superconserved receptors expressed in the brain: Expression, function, motifs and evolution of an orphan receptor family. Stäubert C, Wozniak M, Dupuis N, Laschet C, Pillaiyar T, Hanson J. Pharmacol Ther. 2022 Dec;240:108217. Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels. O’Grady T, Njock MS, Lion M, Bruyr J, Mariavelle E, Galvan B, Boeckx A, Struman I, Dequiedt F. BMC Biol. 2022 Mar 24;20(1):72. GIGA-Neurosciences Product inhibition of mammalian thiamine pyrophosphokinase is an important mechanism for maintaining thiamine diphosphate homeostasis. Sambon M, Pavlova O, Alhama-Riba J, Wins P, Brans A, Bettendorff L. Biochim Biophys Acta Gen Subj. 2022 Mar;1866(3):130071. Recent insights into gap junction biogenesis in the cochlea. Defourny J, Thiry M (2023). Dev Dyn. Feb;252(2):239-246. Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility. Rusidzé M, Faure MC, Sicard P, Raymond-Letron I, Giton F, Vessieres E, Prevot V, Henrion D, Arnal JF, Cornil CA, Lenfant F. Development. 2022 Oct 1;149(19):dev200683. Cyclin-dependent kinase 7 contributes to myelin maintenance in the adult central nervous system and promotes myelin gene expression. Dion V, Schumacher N, Masar N, Pieltain A, Tocquin P, Lesoinne P, Malgrange B, Vandenbosch R, Franzen R. Glia. 2022 Sep;70(9):1652-1665. Neuroendocrine regulation of female aggression. Oliveira VEM, Bakker J. Front Endocrinol (Lausanne). 2022 Aug 10;13:957114. doi: 10.3389/fendo.2022.957114. eCollection 2022. Induction of oxidative stress and alteration of synaptic gene expression in newborn hippocampal granule cells after developmental exposure to Aroclor 1254. Pinson A, Sevrin E, Chatzi C, Le Gac B, Thiry M, Westbrook GL, Parent AS. Neuroendocrinology. 2022 Oct 18:10.1159/000527576. GIGA-Stem Cells A δ-cell subpopulation with a pro-β-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes. Carril Pardo CA, Massoz L, Dupont MA, Bergemann D, Bourdouxhe J, Lavergne A, Tarifeño-Saldivia E, Helker CS, Stainier DY, Peers B, Voz MM, Manfroid I. Elife. 2022 Jan 21;11:e67576. doi: 10.7554/ eLife.67576. Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate. Reuter AS, Stern D, Bernard A, Goossens C, Lavergne A, Flasse L, Von Berg V, Manfroid I, Peers B, Voz ML. PLoS Genet. 2022 Mar 14;18(3):e1010109. Scaling brain neurogenesis across evolution. Malgrange B, Nguyen L. Science. 2022 Sep 9;377(6611):1155-1156. The E3 ligase COP1 promotes ERα signaling and suppresses EMT in breast cancer. Tang SC, Lion Q, Peulen O, Chariot P, Lavergne A, Mayer A, Fuster PA, Close P, Klein S, Florin A, Büttner R, Nemazanyy I, Shostak K, Chariot A. Oncogene. 2022 Jan;41(2):173-190. doi: 10.1038/s41388021-02038-3. Epub 2021 Oct 29.

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