43 HIGHLIGHTED PUBLICATION PROTEOMICS In June 2022, Professor Agnès Noël (GIGA Cancer) was awarded a 900,000 € grant from the Belgian Foundation against cancer for the acquisition of a novel mass spectrometer dedicated to proteomics analysis at the (single) cell level. While waiting for the instrument to be installed, MSLab and GIGA-Proteomics have already investigated sample preparation and novel acquisition method schemes provided by this new generation of mass spectrometers. This was done in syner-gy with the ChipOmics project (Win2WAL). GIGA-Proteomics is collaborating with the laboratory of Rhumatology (Dr. Dominique De Seny) within the ImmunAID European project. The project aims to improve the diagnosis for some sys-temic autoinflammatory diseases that currently rely only on clinical symptoms. To achieve this, GIGA-Proteomics is performing differential proteomics analyses using liquid chromatography hyphenated to mass spectrometry. In 2022, 126 plasma samples that have been depleted and an-alysed by 2D-LC-MS/MS for this project. In February 2023, the new timsTOF SCP has been installed, which will allow researchers to obtain interesting results for differential proteomics even with only a few cells available for analysis. Additionally, this technology will enable real single-cell (sc-) proteomics analysis, which will be de-veloped in 2023. By the end of 2023, these new analyses will be proposed in the GIGA-Proteomics platform portfolio, complementing other «single-cell» type analyses (such as sc- RNAseq) that are already available within the GIGA technological platforms.
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