Fabrice Bureau

Fabrice Bureau has completed two different university studies. After being awarded an undergraduate degree in biology at the Mons-Hainaut University (1989), he embarked upon veterinary medicine studies at the University of Liège. Having received his second undergraduate degree in 1995, Fabrice Bureau started a thesis on airway diseases in horses in the Laboratory of Veterinary Physiology (ULg). After several post-doctoral positions spent refining his knowledge of immunology and asthma, Fabrice Bureau returned to the University of Liège in 2005. He is now a professor of biochemistry at the Faculty of Veterinary Medicine. He is also part of the GIGA where he has created the Laboratory of Cellular and Molecular Immunology, and where he is the director of the Thematic Research Unit devoted to Immunology (GIGA-Inflammation, Infection, and Immunity). The focus of F. Bureau's work is the regulation of immune responses in the respiratory tract. F. Bureau's work has been published in high-ranking immunology journals including Nature Medicine, Immunity, Journal of Clinical InvestigationAmerican Journal of Respiratory and Critical Care MedicineBloodJournal of Allergy and Clinical Immunology etc. 

Selected publications:

 

Host DNA released by NETosis promotes rhinovirus-induced type 2 allergic asthma exacerbation. Toussaint M, Jackson DJ, Swieboda D, Guedan A, Tsourouktsoglou T, Ching YM, Radermercker C, Makrinioti H, Aniscenko J, Edwards MR, Solari R, Farnir F, Papayannopoulos V, Bureau F (co-last author), Marichal T, Johnston SL. (2017) Nature Medicine (IF = 30.4), In press.

 

- Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages. Sabatel C, Radermecker C, Fievez L, Paulissen G, Chakarov S, Fernandes C, Olivier S, Toussaint M, Pirottin D, Xiao X, Quatresooz P, Sirard JC, Cataldo D, Gillet L, Bouabe H, Desmet CJ, Ginhoux F, Marichal T (co-last author), Bureau F. (2017) Immunity (IF = 24.1), 46(3):457-473. doi: 10.1016/j.immuni.2017.02.016.

 

- Lung-resident eosinophils represent a distinct regulatory eosinophil subset. Mesnil, C, Raulier, S (co-first author), Paulissen, G, Xiao, X, Birrell, MA, Pirottin, D, Janss, T, Starkl, P, Ramery, E, Henket, M, Schleich, FN, Radermecker, M, Thielemans, K, Gillet, L, Thiry, M, Belvisi, MG, Louis, R, Desmet, C, Marichal, T (co-last author), Bureau, F. (2016) Journal of Clinical Investigation (IF = 13,2), 126(9):3279-95. doi: 10.1172/JCI85664
Comment in: "A hidden residential cell in the lung", Rothenberg MA,  J Clin, Invest, 2016.

 

- Marichal, T, Ohata, K, Bedoret, D, Mesnil, C, Sabatel, C, Kobiyama, K, Lekeux, P, Coban, C, Akira, S, Ishii, K. J, Bureau, F (co-last author), & Desmet, C. (2011). DNA released from dying host cells mediates aluminum adjuvant activity. Nature Medicine (IF = 27,4), 17, 996-1002.

 

Bedoret, D, Wallemacq, H, Marichal, T, Desmet, C, Quesada Calvo, F, Henry, E, Closset, R, Dewals, B. G, Thielen, C, Gustin, P, De Leval, L, Van Rooijen, N, Le Moine, A, Vanderplasschen, A, Cataldo, D, Drion, P, Moser, M, Lekeux, P, & Bureau, F. (2009). Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. Journal of Clinical Investigation (IF = 13,2), 119, 3723-38.